Acoustic Startle Responses and Prepulse Inhibition of Acoustic Startle Responses in Warsaw Alcohol High-Preferring (WHP) and Warsaw Alcohol Low-Preferring (WLP) Rats
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چکیده
منابع مشابه
NEUROPHYSIOLOGY Acoustic Startle Responses and Prepulse Inhibition of Acoustic Startle Responses in Warsaw Alcohol High-Preferring (WHP) and Warsaw Alcohol Low-Preferring (WLP) Rats
Aims: An assessment of the acoustic startle response (ASR) and prepulse inhibition (PPI) of ASR in laboratory animals is used to model human anxiety and psychotic states, respectively. The aim of the study was to evaluate ASR and PPI in alcoholnaive male and female Warsaw alcohol high-preferring (WHP) and Warsaw alcohol low-preferring (WLP) rats. Methods: ASR and PPI were assessed in two separa...
متن کاملAcoustic startle responses and prepulse inhibition of acoustic startle responses in Warsaw alcohol high-preferring (WHP) and Warsaw alcohol low-preferring (WLP) rats.
AIMS An assessment of the acoustic startle response (ASR) and prepulse inhibition (PPI) of ASR in laboratory animals is used to model human anxiety and psychotic states, respectively. The aim of the study was to evaluate ASR and PPI in alcohol-naive male and female Warsaw alcohol high-preferring (WHP) and Warsaw alcohol low-preferring (WLP) rats. METHODS ASR and PPI were assessed in two separ...
متن کاملOperant self-administration of ethanol in Warsaw high-preferring (WHP) and Warsaw low-preferring (WLP) lines of rats.
The results of the present experiment demonstrate that ethanol-preferring line of rats (WHP), and ethanol-nonpreferring line of rats (WLP) are able to acquire and maintain lever pressing reinforced by EtOH (oral operant EtOH self-administration) under FR-1 and FR-2 schedule of reinforcement. On the other hand, WHP rats but not WLP rats, displayed the high ability to acquire and maintain robust ...
متن کاملDrinking of flavored solutions by high preferring (WHP) and low preferring (WLP) alcohol-drinking rats.
BACKGROUND Selective breeding alcohol-preferring (P) and alcohol-nonpreferring (NP) rats showed a strong preference for the sucrose solutions, whereas P rats intake greater amounts than NP rats. The aim of this study was the estimation of selectively bred ethanol-preferring (WHP - Warsaw High Preferring) and ethanol-nonpreferring (WLP - Warsaw Low Preferring) rats for their preference for vario...
متن کاملPreliminary phenotypic characterization of the Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP) lines of rats selectively bred for high and low ethanol consumption.
The Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP) lines were bred from Wistar foundation stock to obtain lines of rats that differ in their preference for ethanol (EtOH) solutions. The WHP line has met major criteria for an animal model of alcoholism. The WHP rats voluntarily drink excessive amounts of alcohol while the WLP rats consume negligible amounts of alcohol. These patter...
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ژورنال
عنوان ژورنال: Alcohol and Alcoholism
سال: 2012
ISSN: 1464-3502,0735-0414
DOI: 10.1093/alcalc/ags039